Dr Margaret G Wong

Location: Applied Sciences Building: AS227, Hawthorn Campus

Phone: (61 +3) 9214 8542

Fax: (61 +3) 9819 0834

E-mail: marg at freon.chem.swin.edu.au

PGP key: My public key & fingerprint

Links: My bookmark list

Areas of interest

• Molecular Modelling
• Computers in Chemistry
• Medicinal and Organic Chemistry

Courses

• SC390, SC490, SC590, SC690 - Computers in Chemistry
• SC701 - Chemistry/Biochemistry honours (Computational Chemistry)
• SC553 - Applied Chemistry (Synthesis)
• SC560, SC660, SC680 - Practical Chemistry for Chemists and Biochemists
• SC570 - Chemistry (Stereochemistry)
• SC254 - Chemistry (Organic Chemistry)
• SC653 - Applied Chemistry (Analysis of Polymers)

Research activities

• Neurotransmitters; with an emphasis on GABA and NMDA.
• Antifreeze Peptides
• Glutathione Utilizing Enzymes
• The development of Radiopharmaceuticals

Representative publications

1. Analysis of Agonism by Dopamine at the Dopaminergic D₂ Coupled Receptor Based on Comparative Modelling of Rhodopsin.
   Tehan, B.G., Lloyd, E.J. Wong, M.G., Chalmers, D.K.
   Molecular Simulations, 2002, 28 (10-11) 865-888

2. Estimation of pK_a Using Semiempirical Molecular Orbital Methods. Part 1: Application to Phenols and Carboxylic Acids.
   Tehan, B.G., Lloyd, E.J. Wong, M.G., Pitt, W.R., Gancia, E., Montana, J.G., Manallack, D.T.
   QSAR, 2002, 21, 457-472

3. Estimation of pK_a Using Semiempirical Molecular Orbital Methods. Part 2: Application to Amines, Anilines and Various Nitrogen Containing Heterocyclic Compounds.
   Tehan, B.G., Lloyd, E.J. Wong, M.G., Pitt, W.R., Gancia, E., Manallack, D.T.
   QSAR, 2002, 21, 473-485

4. Wong, M.G., Tehan, B.G., Lloyd, E.J. Molecular Mapping in the CNS. Current Pharmaceutical Design, 2002, 8, 1547-1570

5. Beart P M, Ryan M C, Mercer L D, Jarrot B and Wong M G
   Heterocyclic Aminoalcohols related to Ifenprodil as Sigma Ligands: Assessment of their Activity by Radioligand and Quantitative Conformational Analyses.
   Eur J Mol Pharm, 269, 193-200, (1994)

6. Nero T L, Iskander M N and Wong M G
   Transamination of g-Aminobutyric acid; a Semi-empirical Molecular Orbital Study of the Transaminase Mechanism.
   JCS Perkin 2, 431-436, (1993)

7. O'Callaghan D, Wong M G, and Beart P M
   Molecular Modelling of N-Methyl-D-aspartate Receptor Agonists.
   Molecular Neuropharmacology, 2, 89-92 (1992)

8. Nero T L, Wong M G, Oliver S W, Iskander M N and Andrews P R
   Investigation of the active sites of Aspartate Aminotransferase.
   J Mol Graphics, 8, 111-115 (1990)

Other Professional Activities

• Development of chemistry teaching using computers
• The development of computational chemistry teaching modules for access via AARNET, in conjunction with B Salter-Duke (NTU), E J Lloyd (VCP), B Yates (Tas U) and G J Cross (SwinUT). Funding is from a CAUT grant.
• Software Editor; Chemistry in Australia
• Past Chairman, Medicinal & Agricultural Chemistry Division, RACI
• Past Secretary, Melbourne Silicon Graphics User's Group